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KMID : 0363219920300040499
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Korean Journal of Dermatology
1992 Volume.30 No. 4 p.499 ~ p.507
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Investigation of the Pharmacologic Response of Sweat Glands in the Lesions of Psoriasis, Vitiligo and localized Scleroderma(Morphea)-Quanititation of Sweat Using the Skin Surface Hyprometer
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Abstract
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In a previous communication, we described a relatively simple method for assaying quantities of sweat using the skin surface hydrometer. In order to evaluate the pharmacologic response of sweat glands in psoriasis, vitiligo and localized
scleroderma, we
measured the basal skin conductance and the quantity of sweat induced by intradermal injections of pilocarpine nitrate in the lesional and perilesional skin.
@ES The results were as follws:
@EN 1. In psoriatic plaques, basal skin surface hydration and the sweat response to pilocarpine was markedly reduced (p<0.05), but there were no significant differences in normal perilesional skin.
2. In geeralized vitiligo, basal skin surface hydration and the sweat gland response was normal. In the case of the segmental type, there was a slightly decreased sweat response in the lesion but not significnat statistically.
3. In the morphea plaque, basal skin surface hydration and the sweat response to pilocarpine was markedly reduced but was normal in perilesional skin.
This study presents evidence of the functional changes in the development of sweat secretion and surface hydration in the lesions of psoriasis, morphea and segmental type of vitiligo. The demonstration of abnormalities in the pharmacologic
response
to
pilocarpine induction led us to suggest the possibility that some degree of sweat gland involvement is induced by the pathogenetic mechanisms of these diseases.
(Kor J Dermatol 1992;30(4) : 499-507)
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